Tramadol HCl is a centrally acting opioid analgesic used in the treatment of moderate to severe pain in diverse conditions. Combined with low dependence/abuse potential, it has proven to be of significant advantage over other agents, especially in the elderly. Tramadol, is used in acute conditions like postoperative neuralgia or situations when the patient is hospitalized and to treat pain following orthopaedic and gynaecological procedures, including cesarean section. In that condition most of the patients facing problem of swallowing and the patient also need quick onset of action hence Orodispersible tablet of Tramadol HCl is the best option. In present work attempts have been made to formulate and evaluate Orodispersible tablets of Tramadol HCl by using different natural (Plantago ovata mucilage and Sodium alginate) and synthetic superdisintegrants (Crospovidone and Sodium starch glycolate) in different concentration (2, 4, 6 %). Orodispersible tablets were prepared by direct compression technique. The Prepared tablets were evaluated for Weight variation, Friability, Hardness, Thickness & diameter, Uniformity of Drug Content, In-vitro disintegration test, Wetting time, in-vitro dispersion time, in-vitro dissolution study. Formulation F6 prepared from Plantago ovata mucilage (6%) was found to be optimized formulation showed the disintegration time 21 sec, wetting time 20 sec, in-vitro dispersion time 19 sec also the drug was completely released within 5 minutes and the formulation F6 passes tests of weight variation, friability, drug content. Accelerated stability study was done on optimized formulation and the study indicated slight acceptable difference in evaluation parameters.
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